Assume that you have discovered a new chemical mutagen that modifies guanine so that it mispairs with thymine when thymine is in the template DNA strand during DNA replication. However, this mispairing is limited to when the modified guanine is being added to the newly replicating DNA strand. When the modified guanine is in the template DNA strand it always pairs normally, with cytosine being added to the growing newly synthesized strand. What type of mutation would you predict would be caused by the new chemical mutagen
A-C base substitution mutation will be caused by the new chemical mutagen.
When A is in the template strand during the first round of replication, G is added to the new daughter strand as it pairs to A due to mispairing.
It is assumed that this mispairing only occurs when the freshly duplicated strand is being joined to the modified guanine.
C is added to the opposing strand during the second round of replication, when the daughter strand that contains G serves as a template for replication.
Therefore, C has replaced A in the diagram. A was thus removed from the site, and the C-G pair will now fill the space where the A-T pair had been. A was thus replaced by C.
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